منابع مشابه
[Sickle cell disease and infection].
OBJECTIVE To discuss the high prevalence of sickle cell disease in our environment and the increased morbidity and mortality as a result of infection associated with this condition. SOURCES OF DATA Review of MEDLINE from 1986 to 2003. We found around 600 references about the subject. Thirty-five journal articles were reviewed, in addition to chapters in two text books. SUMMARY OF THE FINDIN...
متن کاملSickle Cell Disease and Bartonella Spp. Infection
To the Editor, We read with great interest the recent article role of infection in the pathogenesis of vaso crisis in patients with sickle cell diseases, Dr. Ahmed SG. He pointed that these patients have impaired immunity and are thus predispose to infections which can precipitate the painful crisis. SCD is the most common hereditary hematologic disorder in the world and remains a significant g...
متن کاملIntracardiac Thrombosis in Sickle Cell Disease
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive...
متن کاملInfection in sickle cell disease: a review.
Infection is a significant contributor to morbidity and mortality in sickle cell disease (SCD). The sickle gene confers an increased susceptibility to infection, especially to certain bacterial pathogens, and at the same time infection provokes a cascade of SCD-specific pathophysiological changes. Historically, infection is a major cause of mortality in SCD, particularly in children, and it was...
متن کاملSickle Cell Disease and Sickle Cell Anaemia
Sickle cell haemoglobin (HbS) results from an autosomal recessively inherited mutation in which the 17th nucleotide of the beta globin gene is changed from thymine to adenine and the amino acid glutamic acid is replaced by valine at position 6 in the beta globin chain. [1, 2]Sickle cells have a reduced deformability and are easily destroyed, causing occlusion of the microcirculation and a chron...
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ژورنال
عنوان ژورنال: Jornal de Pediatria
سال: 2004
ISSN: 0021-7557
DOI: 10.2223/jped.1218